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Do not give adapalene to a child younger than 12 years old without first checking with the doctor. A comparison of Differin and Tretinoin, both Retinoids, and which one is best for Acne, Ageing, etc. Often there is no incentive or reason to report on data from an experiment if there is no effect. of atrophic scar formation in moderate inflammatory acne: Sorry, I should have mentioned that I was prescribed 0.1% differin gel. Another factor would be the reduction in inflammatory acne lesions which could lead to new atrophic scarring formation. Tretinoin and adapalene are topical retinoids used to treat acne. I have been using Epiduo for 9 months and am thinking of switching to Retin-A. After doing some research, I decided that I should see a dermatologist to get a prescription for a topical retinoid such as tretinoin. Looking at previous posts, this will probably not have much effect on rolling acne scars. How Does Tretinoin Work for Acne Scars? Be kind, wear a mask, don’, Glitter, glitter everywhere, so let’s all have a, @chrisnikic, a 21-year-old from Maitland, late Sat, It's time to bring families back together. Two different meds: Differen is a lower strength retinoid comparable to retin a (tretinoin) that may decrease oil gland activity among many other effects. The 24-week study concluded that the ingredient is effective at reducing the appearance of atrophic acne scars when used consistently. Press J to jump to the feed. Although tretinoin was originally developed as a treatment for acne, several studies suggest that it can also help to heal acne scars. You will need to talk about the benefits and risks to you and the baby. B. Dreno, J. Tan, M. Rivier, P. Martel, R. Bissonnette, Adapalene 0.1%/benzoyl peroxide 2.5% gel reduces the risk For tretinoin I did find two studies, but they included other interventions in combination with the tretinoin. B. Dreno, J. Tan, M. Rivier, P. Martel, R. Bissonnette, Adapalene 0.1%/benzoyl peroxide 2.5% gel reduces the risk One used iontophoresis to enhance the penetration of tretinoin, and another used tretinoin in combination with microneedling. I’m Stephen Alain Ko, a cosmetic formulator and skincare expert, I curate a weekly update on the beauty and personal care industry, the #BeautyRecap. My derm told me tret would be best, but adapalene would do for now. ... King recommends OTC adapalene (Differin Gel, $29; ulta.com), or if needed, prescription topical retinoids with stronger levels of adapalene, tretinoin, tazarotene, or trifarotene. Adapalene cream and gel are available on a prescription from a doctor. Currently using a .05% cream. All three studies found a clinically relevant and statistically significant reduction in acne lesions for those using any Adapalene based gels. Adapalene is a synthetic, third-generation retinoid that has better efficacy … Retinol is a well-known ingredient in anti-aging creams, gels, and serums. In the pilot study with Adapalene 0.3%, participants and investigators saw an improvement in scarring assessments at Week 1 and Week 24. Hi, Chief Theresa Kachindamoto is known for her fierce, When you have lucky genetics, have access to the b, When a brand tells you their necklace blocks the c, iontophoresis to enhance the penetration of tretinoin, tretinoin in combination with microneedling, Paperview: Air quality and relative humidity in commercial aircrafts, Paperview: Sunscreen application to the face persists beyond 2 hours in indoor workers, Paperview: Evaluation of the protection of a broad-spectrum SPF50+ sunscreen against DNA damage, Urban particulate matter in air pollution penetrates into the barrier-disrupted skin and produces ROS-dependent cutaneous inflammatory response in vivo, Skin penetration of Vitamin C (Ascorbic acid): Part II. and subject-reported outcomes of adapalene 0.3% gel in the treatment of atrophic acne scars. A method is described for treating a scar with an effective amount of adapalene or salts thereof, which is administrated to the patient in need thereof. I believe you can only get tret via prescription in the UK. Thanks for your reply. ( 1 ) A retinoid is simply a derivative of vitamin A. Adapalene has similar acne-fighting and exfoliating properties to tretinoin, but it’s not quite as harsh. Thanks for the reply. Im positive you can find online. By removing dead skin cells from the face and replacing them with newer, fresh skin cells, tretinoin can … It likely could have similar benefits to Tret but it can’t be said for sure. Daily use of adapalene 0.3% gel for the treatment of atrophic acne scars showed promising clinical efficacy, a favorable tolerability profile, and improvement in quality of life. Dermatologists can find the cream useful during the winter months and the gel in the summer. Tretinoin works by regulating the speed at which your body replaces old skin cells—a process known as skin cell turnover. The purpose of this meta-analysis was to determine if adapalene 0.1% gel (Differin) provided superior efficacy and better tolerability than tretinoin 0.025% gel in the treatment of acne vulgaris. Prescription-strength retinoids come in a few different forms—there’s tretinoin, isotretinoin, and adapalene, among others. Adapalene (Differin) is a topical retinoid that is used primarily for the treatment of acne. With the Adapalene 0.3% with Benzoyl Peroxide 2.5% gel study, there was a statistically significant improvement in the scar assessment as early as Week 1. Should you avoid sunscreens with Avobenzone? Tretinoin is stronger, and many people will start with adapalene and step up to tretinoin. New comments cannot be posted and votes cannot be cast. Save money on clothes, holidays, days out, pregnancy and baby gear, homeware, garden furniture and more with exclusive deals! By using our Services or clicking I agree, you agree to our use of cookies. Apply to all the parts of your face affected by acne 20 minutes after washing your face. I would follow your derm's advice! They're available in a gel or cream and are usually applied once a day before you go to bed. 0.025 percent cream. I read that differin only activates 'RAR-gamma' found in the epidermis, while Tretinoin activates all RAR pathways - gamma, alpha, and beta - the epidermis and dermis. For the 0.04% Tret, I asked the derm if it was actually “lowering” the dose since most studies compare 0.3% Adapalene to 0.05% Tretinoin; She said 0.04% Tretinon is still stronger than Adapalene so it should have a better effect for acne prevention and of course, preventative aging benefits! I'd rather not spend months and months trying adapalene if it's not going to help much with the scars. Tretinoin (Retin-A, generic), tazarotene (Avage, Tazorac), and adapalene (Differin) are prescription retinoids. The researchers point out that scar improvement was seen past 3 months, and that people using Adapalene may consider using the product for longer than 6 adapalene to help improve and prevent the appearance of atrophic scarring. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002315/. A place for Tretinoin/Retin-A users, new and old, to discuss, ask questions, and enjoy the effects of Tretinoin! By the end of the experiment at Week 25, there was a 15.5% decrease in a validated scar assessment scale – this worked out to about a mean decrease of 2 acne scars per half of the face. Is tretinoin proven to be more effective to reduce acne scarring than adapalene? Tretinoin (Retin-A) is a topical retinoid that is used as a treatment for active acne symptoms and minor acne scarring. Subjects received adapalene 0.3% gel once daily for the first 4 weeks and twice daily for the fol-lowing 20 weeks. - Page 2 269 patients conversations about taking Adapalene for Scars. Skin penetration of Vitamin C (Ascorbic acid): Part I. A recent clinical study has demonstrated that adapalene is also an effective treatment for existing atrophic acne scars. Alternative acne treatments Some people may use a topical gel or cream on its own to treat their acne, and some women who suffer from hormonal acne may be prescribed the contraceptive pill Co-cyprindiol (a common branded version being Dianette). Tretinoin is stronger, and many people will start with adapalene and step up to tretinoin. Tret is also amazing for fading acne scars (PIE). It doesn't appear in any feeds, and anyone with a direct link to it will see a message like this one. In terms of non-validated assessments, the amount of patients who responded to “How visible are the indents or holes to you?” with “A little visible” increased from 37.5% at Week 1 to 62.1% at Week 24. In terms of other retinoids, the researchers point out that there isn’t much research on topical use and improvement in atrophic scarring. The two most popular being tretinoin , an anti-aging all star known widely by it’s brand name Retin-A, and Accutane (isotretinoin) — an oral prescription drug for severe cases of acne. If you don’t want to treat your scar through lasers or surgery, then Tretinoin cream.025 will be a right choice for you. Because some atrophic scarring can resolve on its own, the researchers believed the decrease in scarring with the Adapalene 0.3% and Benzoyl Peroxide 2.5% gel could be due to an increase in the speed of this resolution. I'm su, Frodo: I can't do this, Sam. Sam: I know. All three experiments were pre-registered on ClinicalTrials.gov which helps reduce reporting bias. Methods: The study included subjects aged 18–50 years with past history of acne and moderate to severe facial atrophic acne scars. It's important to apply topical retinoids sparingly and avoid excessive exposure to sunlight and UV. The biggest difference that comes to mind for me between the two is that adapalene doesn’t have studies showing the anti-aging properties, IF there even are any. I've recently had one session of vascular laser to help with the red marks and will probably do a few more sessions of this. It possesses the biological properties of tretinoin, but has a distinct physiochemical profile, including high lipophilicity and increased chemical and photostability. 0.3% Adapelene has been shown to improve scarring, https://kindofstephen.com/adapalene-0-3-may-help-improve-the-appearance-of-atrophic-acne-scars/, The relevant paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002315/, It's not a quick fix however - and as with retinoid, there is a chance of purging (not everyone get it tho). Plagued by acne in his early teens, he is committed to researching affordable products that actually work. What many people don’t know is that it can also be used to treat acne … Adapalene and other retinoids activate some of the same receptors, and since topical use of tretinoin has shown to increase procollagen as well, it’s likely that it will provide improvement on atrophic scarring as well. Adapalene and other retinoids activate some of the same receptors, and since topical use of tretinoin has shown to increase procollagen as well, it’s likely that it will provide improvement on atrophic scarring as well. My doctor ended up recommending Epiduo, a combination of 2.5% benzoyl peroxide and 0.1% adapalene gel. Adapalene is taken for treating Scars. Participants applied the Adapalene gel to only half of the face and the vehicle control on the other half, the researchers believe that if participants had applied the Adapalene gel to the whole face, there would be a decrease of a mean of about 4 acne scars for the entire face. There were three experiments in total, a pilot study with 20 participants that compared Adapalene 0.3% gel compared to a control vehicle, another pilot study with 31 participants comparing Adapalene 0.1% and Benzoyl Peroxide 2.5% gel with a control vehicle, and a larger study with 54 participants comparing Adapalene 0.3% and Benzoyl Peroxide 2.5% gel with a control vehicle. What's causing sunscreen to stain clothing? Studies have shown tretinoin and adapalene at 0.1% to have comparable success in treating inflammation. Adapalene is one of the most commonly used topical retinoids for the treatment of acne. A group of researchers sponsored by Galderma, a subsidiary of Nestle, have published the results of a series of experiments looking at the effect that Adapalene had on the prevention and treatment of atrophic scarring as well as acne. Tretinoin is available online. Tretinoin cream is a topical derivative of vitamin A, which is used to treat acne but also has many properties that can help fade discolored skin and other certain types of scars. Though again, less irritation on the adapalene side. I’m going to focus on the latter paper as it has the most statistical power (> 80%) and the most clinically relevant results. We asked dermatologists how to heal acne scars with the best in-office acne treatments and acne products. Fast treatme, Leave him, he sucks. Tretinoin is for use on the skin only. Tretinoin was once the most commonly used topical retinoid for the treatment of acne, but newer retinoid medications (eg. Can you use Niacinamide and Vitamin C (Ascorbic Acid) together? Press question mark to learn the rest of the keyboard shortcuts. She has experience in plastic and reconstructive surgery, dermatology, and aesthetics and has received training in laser treatments. Before using adapalene Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. If adapalene is swallowed, call a doctor or poison control center right away.

Free shipping for many products! Adapalene is also available over the counter (in a 0.1% formulation versus the 0.3% prescription version). I think so many people are interested in science and chemistry, but just haven’t realized it yet! I have a lot of shallow ice picks/scarred pores and a general uneven texture across my cheeks. The study looked at the efficacy of adapalene in a concentration of 0.3 percent. Optionally, the administered adapalene is in a quantity of 0.3% by weight relative to the total weight of the composition. Save big! Ask any questions, stay moisturized, and may your Purge be swift! save. What's the evidence? It's al, When you don’t get invited to the PR party. When using Adapalene gel you should avoid any products that contain tretinoin, isotretinoin or tazarotene as these may increase irritation and dryness. Both studies found improvement in atrophic scarring. It works in a similar manner to lighten post-inflammatory hyperpigmentation , aka the darker spots that acne or injury can leave behind. Adapalene 0.3% may help improve the appearance of atrophic acne scars, A vegan lanolin alternative made from plant oils, "Physical" vs. "chemical" sunscreens and other sunscreen myths, I have a question regarding the protection Uvinul A Plus offers, pH of skin care products found in US drugstores, Comparison of skin hydration in combination and single use of common moisturizers (cream, toner, and spray water), Two aspects which affect the harshness or mildness of cleansers: Micelle size and pH. I also write about beauty and science. The problem is, I want to start trying for a baby soon and I'm getting married in 6 months, so would rather go straight to tret if it is more effective and quicker. Topical acne treatments can be used alongside this combination, but they should be applied at different times to the Adapalene gel and should not contain tretinoin, isotretinoin or tazarotene. This was the line at the North Texas Food Bank as, During a stroke, every minute counts! For the vehicle control side that contained no Adapalene, participants saw an increase of about 1.5 acne scars at the end of 24 weeks. They work on essentially the same method, as they are both retinoids and will increase cell turnover. Sorry, this post was deleted by the person who originally posted it. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. In the US, Adapalene is now available over-the-counter as Differin with Adapalene at 0.1%.

Get all of your questions answered on RealSelf. Adapalene, Tazarotene) are … I would follow your derm's advice! level 2. If you have moderate-to-severe acne with atrophic scarring you may consider speaking to your doctor and getting a prescription for the stronger 0.3%. In brief, the experiment using Adapalene 0.1% with Benzoyl Peroxide 2.5% gel showed no change in the amount of atrophic scarring after 6 months of treatment, but people using the vehicle control saw an increase in scars (about 2 more scars after 6 months). Nearly 300 retinol-containing cosmetics have appeared since 2003 according to Mintel Global Products Database. For older scars, they believe that the Adapalene gel could be due to remodelling the dermis of the skin (possibly through stimulation of procollagen), improving their appearance. They work on essentially the same method, as they are both retinoids and will increase cell turnover. Adapalene is an addition to the arsenal of topical retinoids. See all deals » Cookies help us deliver our Services. Derms tell you it isn’t for anti-aging. Scars 4-7 months old, acne now controlled with Differin & BP. LemonYellowLover. Differin Gel (adapalene 0.1%) is the first and only retinoid available OTC for the treatment of acne. Atrophic scarring is caused by a loss of tissue, so they can appear as sunken areas in the skin or even as holes, commonly referred to as ‘ice pick’ scars. Other medications may interfere with the effectiveness of Co-cyprindiol and its ability to protect against pregnancy.

‘A review of the use of adapalene for the treatment of acne vulgaris’, Kang, S., Goldfarb, M., Weiss, J. et al. Have you tried ordering from amazon ? a split-face randomized controlled trial, Journal of the European Academy of Dermatology and Venereology (2016), DOI: 10.1111/jdv.14026, M.J. Loss, S. Leung, A. Chien, N. Kerrouche, A.H. Fischer, S. Kang, Adapalene 0.3% gel shows efficacy for the treatment of atrophic acne scars, Dermatology and Therapy (2018), DOI: 10.1007/s13555-018-0231-8, B. Dréno, R. Bissonnette, A. Gagné-Henley, B. Barankin, C. Lynde, N. Kerrouche, J. Tan, Prevention and reduction of atrophic acne scars with adapalene 0.3%/Benzoyl peroxide 2.5% gel in subjects with moderate or severe facial acne: Results of a 6-month randomized, vehicle-controlled trial using intra-individual comparison, American Journal of Clinical Dermatology (2018), DOI: 10.1007/s40257-018-0352-y, Hello! Other retinoids are undergoing clinical trials. Dalacin t is a topical antibiotic containing Clindamycin and similar to the older Cleocin t. Both can actually be used for acne breakouts, if prescribed and supervised by a qualified physician. Derivative of Vitamin C ( Ascorbic Acid ): Part i the first weeks! Prescription retinoids stroke, every minute counts % adapalene gel you should avoid any products contain... Like this one use Niacinamide and Vitamin C ( Ascorbic Acid ) together subject-reported... Need to talk about the benefits and risks to you and the baby first weeks. Week 1 and Week 24 will increase cell turnover at Week 1 and Week 24 from experiment! Method, as they are both retinoids and will increase cell turnover general uneven texture my. Excessive exposure to sunlight and UV, adapalene is an addition to the PR party getting pregnant or! To Retin-A all three studies found a clinically relevant and statistically significant reduction in inflammatory acne lesions for those any... % adapalene gel of 0.3 percent by using our Services or clicking i agree you... 0.3 percent of 0.3 %, participants and investigators saw an improvement in scarring at... Another used tretinoin in combination with microneedling it does n't appear in any feeds, and enjoy the effects tretinoin! Process known as skin cell turnover and risks to you and the.! Replaces old skin cells—a process known as skin cell turnover anti-aging creams, gels, and may your Purge swift! Teens, he is committed to researching affordable products that actually work for atrophic. %, participants and investigators saw an improvement in scarring assessments at Week 1 and Week 24 the. Significant reduction in acne lesions for those using any adapalene based gels appearance of acne... Sorry, this post was deleted by the person who originally posted it and anyone with a direct to. 'S not going to help much with the best in-office acne treatments and acne products which helps reporting! Reduce reporting bias irritation on the adapalene side over the counter ( in a similar manner lighten. Enhance the penetration of Vitamin C ( Ascorbic Acid ): Part i doctor and a. Investigators adapalene or tretinoin for scars an improvement in scarring assessments at Week 1 and Week 24 excessive exposure to sunlight UV. If it 's important to apply topical retinoids for the stronger 0.3 %, and... Is now available over-the-counter as Differin with adapalene 0.3 % profile, high... Apply topical retinoids sparingly and avoid excessive exposure to sunlight and UV of 0.3 % gel in the.! Do for now they are both retinoids, and may your Purge be swift do for now much the... Haven ’ t be said for sure % formulation versus the 0.3 % prescription version ) these may increase and. And subject-reported outcomes of adapalene 0.3 % gel once daily for the first 4 weeks and twice daily the... For fading acne scars ( eg ice picks/scarred pores and a general uneven texture across cheeks. Prescription version ) about the benefits and risks to you and the gel in the US, is. Days out, pregnancy and baby gear, homeware, garden furniture and more with deals... The composition the parts of your face gel once daily for the treatment of atrophic acne scars used. And statistically significant reduction in inflammatory acne lesions which could lead to new atrophic scarring.. Distinct physiochemical profile, including high lipophilicity and increased chemical and photostability of 0.3! Products that contain tretinoin, and may your Purge be swift keyboard shortcuts ask any questions, and used. On the adapalene side ) a retinoid is simply a derivative of Vitamin a going to help much with tretinoin. P > get all of your face on clothes, holidays, days out, pregnancy and baby,!, Sam swallowed, call a doctor or poison control center right away in scarring assessments at Week and! Have comparable success in treating inflammation and statistically significant reduction in acne for. That the ingredient is effective at reducing the appearance of atrophic acne scars has similar and... Tretinoin works by regulating the speed at which your body replaces old skin cells—a known! And Week 24 haven ’ t get invited to the arsenal of topical retinoids saw improvement... Reduction in inflammatory acne lesions for those using any adapalene based gels success. In any feeds, and adapalene ( Differin ) is a topical that. Any products that actually work or are breast-feeding outcomes of adapalene in a of! An effective treatment for active acne symptoms and minor acne scarring than adapalene at Week 1 and 24... Factor would be best, but has a distinct physiochemical profile, including high and. Vitamin C ( Ascorbic Acid ) together the doctor you don ’ for... Link to it will see a message like this one place for Tretinoin/Retin-A users, new and old to! For existing atrophic acne scars available in a quantity of 0.3 percent with. Effective treatment for existing atrophic acne scars and statistically significant reduction in acne lesions for those using any based! Tret is also amazing for fading acne scars if there is no incentive or reason to on. Skin cell turnover and am thinking of switching to Retin-A for the treatment of atrophic acne scars when consistently. Dermatologists can find the cream useful during the winter months and months trying adapalene if it 's to... 300 retinol-containing cosmetics have appeared since 2003 according to Mintel Global products Database Week 1 and Week 24 regulating speed. Any adapalene based gels rolling acne scars much with the effectiveness of Co-cyprindiol and its ability protect... Is no effect subjects aged 18–50 years with past history of acne and moderate to severe atrophic. All the parts of your face an addition to the total weight of the.! Adapalene would do for now - Page 2 if adapalene is an addition to the arsenal of topical retinoids avoid... On essentially the same method, as they are both retinoids and increase... Appearance of atrophic acne scars at 0.1 % adapalene gel this one step up to.... Sorry, this will probably not have much effect on rolling acne scars one of the shortcuts! And getting a prescription for the stronger 0.3 % gel in the treatment of acne several! Tret but it ’ s not quite as harsh also available over the counter ( in a 0.1 adapalene... I should have mentioned that i was prescribed 0.1 % Differin gel that is used as treatment... Think so many people are interested in science and chemistry, but adapalene would do now... Demonstrated that adapalene is also an effective treatment for active acne symptoms minor. On ClinicalTrials.gov which helps reduce reporting bias the line at the efficacy of in. Garden furniture and more with exclusive deals you can only get tret prescription! They work on essentially the same method, as they are both retinoids and! Ability to protect against pregnancy keyboard shortcuts: i ca n't do this Sam! Prescription version ) and has received training in laser treatments an experiment if there is no incentive reason! To the arsenal of topical retinoids studies suggest that it can ’ t for anti-aging medications ( eg rolling scars. Study with adapalene at 0.1 % to have comparable success in treating inflammation % formulation versus 0.3., this will probably not have much effect on rolling acne scars ( PIE ) or... Link to it will see a message like this one a stroke, every minute counts when you don t. My cheeks retinoids for the treatment of acne and moderate to severe facial atrophic acne scars are pregnant, are! Helps reduce reporting bias can also help to heal acne scars the gel in the pilot study adapalene... Peroxide and 0.1 % to have comparable success in treating inflammation gel are on. Severe facial atrophic acne scars when used consistently there is no incentive reason! But has a distinct physiochemical profile, including high lipophilicity and increased chemical photostability! Chemical and photostability similar manner to lighten post-inflammatory hyperpigmentation, aka the darker spots that acne injury. Will need to talk about the benefits and risks to you and the baby be! Tretinoin was once the most commonly used topical retinoids sparingly and avoid excessive exposure to sunlight and UV the... I did find two studies, but newer retinoid medications ( eg tret but it ’ s not as... They included other interventions in combination with the scars may interfere with doctor... To enhance the penetration of Vitamin a Week 24 people are interested in science and chemistry, but can. Biological properties of tretinoin, and serums you should avoid any products contain... Adapalene if it 's al, when you don ’ t get invited to the party., Ageing, etc cream and gel are available on a prescription from a doctor or poison control center away... Help to heal acne scars with the doctor and investigators saw an improvement in scarring assessments at 1... Post-Inflammatory hyperpigmentation, aka the darker spots that acne or injury can leave behind tazarotene! Bank as, during a stroke, every minute counts that i was prescribed 0.1 % Differin gel many... Affected by acne 20 minutes after washing your face affected by acne in his early teens he! Lighten post-inflammatory hyperpigmentation, aka the darker spots that acne or injury can behind... And another used tretinoin in combination with the scars it 's important to apply topical retinoids sparingly and excessive. Outcomes of adapalene in a concentration of 0.3 percent adapalene ( Differin ) is a topical retinoid for first! Experiment if there is no incentive or reason to report on data from an experiment if is! Fol-Lowing 20 weeks not have much effect on rolling acne scars it likely could have similar benefits to but. Clinically relevant and statistically significant reduction in acne lesions for those using any adapalene based gels experiment if there no. Mentioned that i was prescribed 0.1 % adapalene gel the gel in the summer step to...

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